Reflections, Reconciliation & Repsychopathologization

Stella, Mia, and Bret recap the major events of 2025: Trump’s executive orders and the HHS report, the For Women Scotland Supreme Court ruling, the UK PATHWAYS puberty blockers trial, the McMaster systematic reviews, and Alberta’s use of the notwithstanding clause. Mia gives the Canadian perspective, where things have gone the other way. They also discuss the gap between Britain’s legal wins and what’s actually happening clinically, and why Genspect was raising the alarm about PATHWAYS back in late 2024.

They reflect on their interviews with Gordon Guyatt and Ken Zucker, Susan Bradley’s willingness to say “we were wrong,” and what Mia calls the upstream problem: the belief that being trans is innate and healthy. They finish with predictions for 2026 and whether another social contagion involving bodily harm could follow.

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References and Resources

US Executive Orders & HHS Report

• Executive Order: Defending Women From Gender Ideology Extremism (Jan 20, 2025): https://www.whitehouse.gov/presidential-actions/2025/01/defending-women-from-gender-ideology-extremism-and-restoring-biological-truth-to-the-federal-government/

• Executive Order: Protecting Children From Chemical and Surgical Mutilation (Jan 28, 2025): https://www.whitehouse.gov/presidential-actions/2025/01/protecting-children-from-chemical-and-surgical-mutilation/

• HHS Report: https://opa.hhs.gov/gender-dysphoria-report

UK Developments

• The Cass Review Final Report (April 2024): https://cass.independent-review.uk/home/publications/final-report/

• For Women Scotland Supreme Court Judgment (April 16, 2025): https://supremecourt.uk/cases/uksc-2024-0042

• PATHWAYS Trial – King’s College London: https://www.kcl.ac.uk/research/pathways-trial

• Genspect’s campaign to stop the https://genspect.org/puberty-blocker-trial/

McMaster Systematic Reviews (January 2025)

• Puberty Blockers Review: https://pubmed.ncbi.nlm.nih.gov/39855724/

• Hormone Therapy Review: https://pubmed.ncbi.nlm.nih.gov/39855725/

• McMaster Statement on the Reviews: https://hei.healthsci.mcmaster.ca/systematic-reviews-related-to-gender-affirming-care/

Canada & Alberta

• Alberta Bill 26 Overview: https://www.alberta.ca/advancing-policies-to-support-the-health-care-system

• CBC: Alberta Invokes Notwithstanding Clause (Nov 2025): https://www.cbc.ca/news/canada/edmonton/alberta-government-notwithstanding-clause-bills-9.6983786

Repsychopathologization

• Mia Hughes – The Battle Upstream:

The Battle Upstream: Challenging the false belief causing medical harm

• Restoring Clinical Clarity on Gender Distress: https://genspect.org/restoring-clinical-clarity-on-gender-distress/

• WPATH Depathologization Timeline: https://genspect.org/resources/depathologization-campaign-timeline/

• Why the Drive for Medical Transition:

Why The Drive For Medical Transition Should Be Re-Psychopathologized

Other References

• WPATH Files (March 2024): https://environmentalprogress.org/big-news/wpath-files

• Maya Forstater EAT Judgment (June 2021): https://www.gov.uk/employment-appeal-tribunal-decisions/maya-forstater-v-cgd-europe-and-others-ukeat-slash-0105-slash-20-slash-joj

• JD Vance on Joe Rogan #2221 (Oct 31, 2024):

Past Episodes Referenced

• Ray Blanchard:

The Man Who Named Autogynephilia

• Susan Bradley:

"They're Nearly All Gay or Lesbian"—What This Gender Clinic Founder Learned in 50 Years

• Ken Zucker:

The Man Who Wrote the DSM Gender Diagnoses Breaks His Silence on Why It All Went Wrong

• Allen Frances:

Psychiatric Diagnoses Should Always Be Written in Pencil - Dr. Allen Frances

• Gordon Guyatt:

Gordon Guyatt's Confession: What the Father of Evidence-Based Medicine Didn't Read

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Thank you to everyone who’s listened to and supported the show this year. What was your favorite episode? Who do you hope to see interviewed in 2026?